Article

A new approach to forced degradation studies using zolmitriptan tablets by a sensitive liquid chromatographic method

Author : Nannapaneni Usha Rani, Rayapati Sreenivasa Rao

Forced degradation is a process that involves degradation of drug products and drug substances at conditions more severe than accelerated conditions and thus generates degradation products that can be studied to determine the stability of the molecule. Chemical stability of pharmaceutical molecules is a matter of great concern as it affects the safety and efficacy of the drug product. Zolmitriptan is a drug used for medication in the treatment of migraines and cluster headaches. This paper focuses on developing forced degradation methods for Zolmitriptan and validated the stability of the Zolmitriptan under different testing conditions. The results obtained from the stress testing show that zolmitriptan drug substance is particularly unstable under acidic, hydrolytic, alkaline, oxidative, photolytic conditions and also thermal degradation process. The results also indicate that the described method is suitable for quantitative determination and the stability study of zolmitriptan.


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