Article

A study on demographic profile and cell proliferative activity in Oral Lichen Planus (OLP) and Oral Epithelial Dysplasia (OED) using Ki-67 marker

Author : G. Shailaja, J. Vijay Kumar, P. V. Baghirath, U. Kumar, G. Ashalata, A. Bhargavi Krishna

Background: In oral lichen planus (OLP), destruction of the basal cell layer, which is one of the characteristic histological features, is seen and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium. Lichen planus is a mucocutaneous disease, and its potential for malignant transformation is a subject of controversy. Objective: This study aimed to study on demographic profile and evaluate Ki-67 expression in OLP and OED. Materials and Methods: A cross-sectional study was carried out in 60 samples, categorized Group 1 (30 OLP) and Group 2 (30 OED) samples. Four µm thick sections were obtained and stained with monoclonal antibodies such as Ki-67 and analysed for number of positive cells and also for intensity of staining. Statistical analysis was done by using Mann Whitney–U test (P≤0.05). Results: Significant results were found only for expressions of Ki-67 in both study groups (p<0.05).


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