Acute and subacute toxicity study of ‘Peptoshis’, a digestive disorder protective polyherbal formulation in Wistar albino rat

Author : Tushar Kanti Bera, Kishalay Jana, Sanjit Kumar Kar and Debidas Ghosh

Present study focused the toxicity screening of ‘Peptoshis’, a polyherbal formulation composed of thirteen medicinal plants for the management of digestive disorders i.e. indigestion, constipation, loss of appetite, dyspepsia etc. As oxidative stress is one of the consequences of digestive disorders so the activities of hepatic and pancreatic antioxidant enzymes along with lipid peroxidation levels were evaluated. For acute toxicity evaluation of ‘Peptoshis’, it was administered orally at the dose ranging from 25, 50, 100, 200, 400, 800, 1600, 3200 mg/kg body weight. Insignificant variations were noted in antioxidant enzymes (i.e. catalase, glutathione-S-transferase, super oxide dismutase) activities along with the lipid peroxidation level in between vehicle control (Group-I) and Peptoshis treated control (Group-II) animals. Treatment of ‘Peptoshis’ to the control animals (Group-II) did not reflect any significant variation in the levels of hematological and liver function test (LFT) biosensors in respect to the vehicle control animals (Group-I). Acute toxicity study illustrate, there was no toxic symptom up to the dose level of 3200 mg/kg. From these results, it may be stated that ‘Peptoshis’ at the dose of 50 mg/kg is safe for long term treatment of digestive disorders management

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