Article

An improved, scalable and roboust process for the synthesis of cilastatin sodium: A renal dehydropeptidase inhibitor

Author : Sachin Sonavane, Ravindra Pagire, Dayaghan Patil, Uttam Pujari, Rohan Nikam and Nitin Pradhan

An improved process developed for the synthesis of API, Cilastatin Sodium with more than 99.5% purity and all impurities well below the regulatory limits. The process was specially modified to control the epimeric impurities; solvent purification methods have been developed to achieve desired quality of API without any use of either column chromatography or ion-exchange chromatography.


Full Text Attachment

Creative Commons License World Journal of Pharmaceutical Science is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at www.wjpsonline.org. Permissions beyond the scope of this license may be available at www.wjpsonline.org.