Analytical and Bio-analytical Methods of Telbivudine: A Review

Author : M. GnanaChandrika, M. Vamsi Krishna and K. Padmalatha

Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine acts by inhibiting HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate, thymidine 5'–triphosphate. This leads to the chain termination of DNA synthesis, thereby inhibiting viral replication. HPLC and LC-MS/MS methods have been reported for the estimation of telbivudine in bulk drugs, pharmaceutical formulations and biological fluids. In this review we have presented the different analytical and bio-analytical methods reported for the telbivudine.

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