Anti-inflammatory and anti-oxidant activity of Dialium dinklagei Harms. (Leguminosae)

Author : Gina Ramos, Elikplim Kwesi Ampofo, Abraham Yeboah Mensah, Francis Mainoo Sarpong, Isaac Kingsley Amponsah

Dialium dinklagei is a plant used in the management of pain, arthritis, rheumatism, pulmonary diseases and as a laxative in Ghanaian folklore medicine. However there is no scientific validation of these pharmacological activities. Therefore in this research, the anti-oedematogenic and antioxidant activity of a hydro-ethanolic extract of D. dinklagei was evaluated. In vivo anti-inflammatory activity was done by the carrageenan induced oedema in 7 day old chicks. The antioxidant activity was investigated in vitro by the DPPH radical scavenging and phosphomolybdenum total antioxidant capacity assays. D. dinklagei exhibited a dose-dependent anti-inflammatory activity with ED50 of 10.6 mg/kg body weight compared to diclofenac sodium (ED50 = 4.03 mg/kg body weight). It showed considerable antiradical activity (EC50 = 39.6) and a total antioxidant capacity of 581.58 mg of vitamin C per gram of extract. The phytochemicals tannins, alkaloids and terpenoids present in the plant could be responsible for its anti-inflammatory and antioxidant effects. Thus the present study has given scientific credence to the use of D. dinklagei in ethnomedicine for the management of painful inflammatory conditions

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