Anti-inflammatory and antioxidant activity of the ethanolic stem bark extract of Pachypodanthium staudtii engl. & diels (Family Annonaceae)

Author : Francis Mainoo Sarpong, Isaac Kingsley Amponsah, Francis Ackah Armah, Yakubu Jibira, Racheal Gyamfi

Pachypodantium staudtii Engl. & Diels, is widely distributed in West Africa and used indigenously for the treatment of pain and inflammatory conditions but has not been validated for these purported uses. Ethanolic extract of Pachypodantium staudtii was evaluated for its anti-inflammatory and anti-oxidant activities. Anti-inflammatory effect of the extract was assessed using the carrageenan-induced oedema in chicks whereas antioxidant activity was evaluated using the total antioxidant capacity and DPPH radical scavenging assays. The extract showed a dose dependent inhibition of oedema with maximal percentage inhibition of 68.74% at 300 mg/kg body weight. It also showed significant antioxidant activities. Coumarins, flavonoids, alkaloids and other phytochemicals found in the plant could be responsible for these activities. Thus the present studies have given scientific credence to the folkloric use of P. staudtii for the treatment of pain and inflammation.

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