Article

Anticoagulant evaluation of 1,3,4-oxadiazole derivatives derived from benzimidazole

Author : B. Vishwanathan and B.M. Gurupadayya

In the present study, a series of 1,3,4-oxadiazole derivatives (4a-4k) derived from benzimidazole were evaluated for ex vivo anticoagulant activity. The anticoagulant study was performed for increase in prothrombin time (PT) and activated partial thromboplastin time (aPTT) at a test dose of 25 mg kg-1. The results of ex vivo anticoagulant evaluation revealed that the tested compounds 4a-4k exhibited moderate increase in PT with respect to acenocoumarol (1 mg kg-1) employed as reference drug for increase in PT. While the compounds 4a-4k exhibited minimal increase in aPTT in comparison to unfractionated heparin (500 IU kg-1) employed as reference drug for increase in aPTT. Compounds, 4c, 4b and 4k exhibited substantial anticoagulant activity with increase in PT 32 0.7, 36 0.5 and 41 0.4 s, respectively to that of the reference drug acenocoumarol (48 0.5 s).


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