Antihyperlipidemic and antiobesity activity of ethanolic extract of Benincasa hispida fruits on hyperlipidemic rats

Author : Krishna Mohan Chinnala, Madhan Mohan Elsani, Santhosh Sarvu

Hyperlipidemia and obesity are the common and challenging health problems throughout the world. These are the conditions in which increased lipid levels in blood are the risk factors for atherosclerosis, coronary artery diseases and cerebral vascular diseases. In the present study the absolute ethanolic extract of Benincasa hispida was examined for its antihyperlipidemic effect and antiobesity activity in olive oil induced Wistar albino rats. Normal and olive oil induced hyperlipidemic rats were pretreated with single daily administration of 10ml/kg distill water, 20mg/kg simvasatin, 200mg/kg and 400mg/kg Benincasa hispida fruit extract orally, for 28 days for every 24 hours in each group (II, III, IV and V) except control. The activity was assessed by estimation of body weight, liver weight, food intake, serum lipid profile etc. The bio chemical parameters like Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C), Very low density lipoprotein cholesterol (VLDL-C), atherogenic index, Blood glucose levels and histopathology of liver were also assessed. The graded doses of Benincasa hispida extract significantly reduced the weight gain pattern of body and liver and causes dose related reduction in serum lipids, atherogenic index and blood glucose. The present study demonstrated that Benincasa hispida extract shows both antihyperlipidemic and antiobesity effects, which may be partly mediated by anorectic effect, probably through CNS mediation, with no effect on gastric emptying, and inhibition of denovo biosynthesis of cholesterol.

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