Article

Antitumor activity of Leucopyrosinol isolated from the leaves parts of Fluggea leucopyrus

Author : Nagarathna P.K.M, Dhafer Shaher, Rosey Sarraf, Shemin S. Dani

The objective of the present study was to evaluate the anti-tumor activity of Leucopyrosinol isolated from the leaves parts of Fluggea leucopyrus. Antitumor activity of Fluggea leucopyrus against EAC was determined using single dose and intermittent treatments over two weeks, i.e. four-drug administration by the intrapretonial route on days, 1, 5, 9, and 11 after EAC cells inoculation. The compound and the vehicle were administered I.P using 10 mice per test group. Results indicated that there was significant increase in life span and reduction in the tumor volume in Fluggea leucopyrus treated mice. The results of the study strongly demonstrate that Fluggea leucopyrus exhibited significant antitumor activity against EAC in mice.


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