Appraisal of Radical Scavenging Activities and Phytochemical Constituents of the Aerial Part Extracts of Guizotia scabra (Vis.) Chiov

Author : Etsay Weldekidan, Gomathi Periyasamy, Biruk Sintayehu, Mebrahtom Gebrelibanos, Abera Hadigu, Raghavendra Yarlagadda

Guizotia scabra (family Asteraceae) is a wild edible and medicinal plant native to Africa. It is widely used for treatment of myriads of diseases associated with oxidative stress, and this study aimed at evaluating the 1, 1-diphenyl-2-picrylhyorazyl (DPPH) radical scavenging activity and detecting major phytochemical constituents of extracts from the aerial part of G. scabra. The aqueous and 80% methanolic crude extracts prepared by decoction and by maceration, respectively as well as the different solvent fractions prepared from each of them showed considerable DPPH scavenging activity with IC50 ranging from 11.66-55.60 g/ml. The n-butanol fraction prepared from the aqueous crude extract of the aerial part of G. scabra showed the most potent DPPH scavenging activity (IC50=11.66 g/ml) next to ascorbic acid (IC50=1.23 g/ml). Phytochemical screening on both the aqueous decoction and 80% methanol crude extracts showed the presence of polyphenols, flavonoids, saponins, and phytosteroids. In conclusion, the aerial part of G. scabra contains phytochemicals with marked radical scavenging activity that could at least partly justify the traditional use of the plant for treatment of different diseases associated with oxidative stress and its potential as source potent antioxidants.

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