Effect of β-lactam antibiotics on motor coordination in mice

Author : R. Kavitha, N. Seethalakshmi, P. Arumugam and R. Kannan

Background: Glutamate is the major excitatory amino acid transmitter in the brain playing an important role in synaptic plasticity which helps in cognitive functions such as learning and memory, motor coordination and locomotor activity. Beta lactam antibiotics have shown to enhance the uptake of Glutamate via activation of the genetic promoter for GLT-1.The present study was undertaken to evaluate the effect of Beta lactam antibiotics on motor coordination in mice. Methods: Swiss albino mice of either sex were grouped into three and treated with Ampicillin-240mg/kg, Amoxicillin+Clavulanic acid-200mg/kg and Ceftriaxone-200mg/kg for 14 days respectively. The motor coordination of these animals were evaluated using Rotarod before and after administration of beta lactam antibiotics on 1st day, 7th day and 14th day. Results: A significant increase in the motor coordination among the three groups in mice was observed from before administration to 1st day, 1st to 7th day, 7th to 14th day and before to 14th day (P<0.001). However, there were no significant differences in motor performance between the three groups treated with Ampicillin, Amoxicillin+Clavulanic acid and Ceftriaxone (P>0.05). Conclusions: These results suggest that there is an improvement in the motor performance after administration of Beta lactam antibiotics in mice.

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