Article

Effect of Azithromycin and Rosuvastatin on animal models for skeletal muscle relaxant activity in Swiss albino mice

Author : Rajesh M, Priyadarshini P, Patric Joshua P

The objective of the study was to evaluate the effect of Azithromycin and Rosuvastatin on animal models for skeletal muscle relaxant activity in Swiss Albino Mice by using Rotarod and actophotometer. Statins affect skeletal muscle contraction and it is metabolized by CYP3A4. Macrolide antibiotics inhibit CYP3A4 and it can be co-administered along with statins. For this study 30 healthy albino mice were randomly selected and divided into 5 equal groups. Rota rod test and Locomotor activity by Actophotometer was observed for 5mins before and after intragastric administration of distilled water 0.5ml, Diazepam (4 mg/kg), Azithromycin 100mg/kg, Rosuvastatin 2mg/kg and combination of Azithromycin (100mg/kg) + Rosuvastatin (2mg/kg) to mice of group 1 to 5 respectively. The results were analyzed statistically. Rosuvastatin and Azithromycin produced no significant effect on motor coordination and locomotor activity in albino mice.


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