Article

Effect of chronic use of tadalafil on prostate-specific anti-gene and oxidative stress in obese diabetic patients

Author : Haedar Abdulhafith Al-biati, Ahmed Salih Sahib, Faris Abdul Kareem Kazaal, Salim Al-Rubaie

A strong and independent association between obesity, diabetes mellitus and elevation of specific prostate – antigene has been widely evidenced in several clinical epidemiologic studies. Preclinical animal models have provided a great deal of information on potential common pathogenic mechanisms underlying these clinical identities. Phosphodiesterase-5 (PDE-5) inhibitors restore NO signaling may improve metabolic parameters through a number of mechanisms. We hypothesized that daily administration of the PDE-5 inhibitor; Tadalafil 10 mg daily will improve metabolic parameters, oxidative stress markers, anti-inflammatory parameters, PSA and body weight in obese diabetic patients and these parameters decreases serum level of prostate –specific anti-gene. Totally, 25 obese diabetic male patients with metabolic syndrome treated with Tadalafil 10 mg daily for three months. Body weight, FPG levels, HbA1C, HOMA-IR, serum prostate-specific antigene, IL-6 and oxidative stress markers were determined monthly. Treatment with tadalafil caused a reduction in fasting glucose levels, HbA1c, HOMA-IR, IL-6, PSA, oxidative stress markers and body weight which were significantly reduced. Tadalafil 10 mg therapy once daily is a safe and effective treatment option for benign prostate hyperplasia glycemic control, and body mass index in diabetic patients with metabolic syndrome.


Full Text Attachment

Creative Commons License World Journal of Pharmaceutical Science is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at www.wjpsonline.org. Permissions beyond the scope of this license may be available at www.wjpsonline.org.