Estimation of Metformin Hydrochloride by UV Spectrophotometric Method in Pharmaceutical Formulation

Author : Ambadas R. Rote, Ravindranath B. Saudagar

A simple and sensitive UV spectrophotometric method has been developed and validated for the estimation of metformin hydrochloride in tablet formulation. Metformin hydrochloride is determined spectrophotometrically at 232 nm using distilled water as solvent. It obeyed Beer\'s law in the range of 2-10 μg/ml. Percentage recovery of the drug for the proposed method ranged from 102-105% indicating no interference of the tablet excipients. The proposed method was found to be accurate and precise for routine estimation of metformin hydrochloride in bulk and pharmaceutical formulation.

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