Article

Experimental Evaluation of Newer Non-Benzodiazepine (BZD) Hypno-Sedatives Using Different Animal Models

Author : Manohar M. Bende, Uma A. Bhosale

Objectives: To evaluate hypno-sedative action of 'Z'-drugs; Zopiclone and Zolpidem by using animal models for hypnosis and sedation (anxiolysis); and to further evaluate their effect on memory-learning in albino mice. Methods: Pharmacological assays used for evaluating hypno-sedative action are righting reflex test, Pentobarbitone sleeping time potentiation test, Open field apparatus (OFT) and Elevated plus maze (EPM). While EPM retention test was used to study effect on memory-learning in albino mice. Data analyzed by studentísĎtí-test and Chi-square (X2) test; p<0.05 considered significant Results: Zopiclone (7.5mg/kg) and Zolpidem (10mg/kg) p.o. did not inhibit the Righting reflex however cause significant (p<0.001) potentiation of Pentobarbitone sleeping time. Both the drugs significantly (P<0.001) increased ambulation and exploration in OFT as well as performance in EPM suggestive of anxiolysis. Whereas significant (p<0.05) decrease in transfer latency (TL) on Day II in EPM retention test was observed only with Zopiclone treated group of animals. Conclusions: Zopiclone (7.5mg/kg) and Zolpidem (10mg/kg) both have promising selective hypno-sedative activity compared to BZDs. Zopiclone however scores over Zolpidem with respect to lack of memory-learning impairment.


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