Exploration of cytotoxic and antioxidant potential of Antigonon leptopus (Family: Polygonaceae)

Author : Lopamudra Pradhan and Sunita Bhatnagar

Antigonon leptopus leaf extracts were explored for their phytochemical, antioxidant and cytotoxic activity. Four solvent extracts namely hexane, chloroform, ethyl acetate and methanol extracts were prepared. All extracts showed the presence of one or the other important class of compounds, like hexane was positive for flavonoids, whereas sapponins and tannins were present in methanol extract. Ethyl acetate extract showed very good antioxidant activity in TLC based assay and mild to good antioxidant activity in DPPH radical scavenging, FRAP and Nitric oxide radical scavenging assays. Ethyl acetate extract also exhibited mild cytotoxic activity (55%) in brine shrimp assay at a higher dose of 200microgram/ml.

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