Formulation and Evaluation of nanoparticles loaded with Escitalopram using intelligent Biomaterial isolated from the fruit pulp of Ficus carica

Author : Laxmi Goswami, N.V. Satheesh Madhav and Kumud Upadhyaya

The purpose of the present study was to formulate and evaluate Escitalopram loaded bio-nanoparticles for effective treatment of Depression. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Ficus carica by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, color changing point and chemical test. Bio-nanoparticles were prepared by modified solvent evaporation method in different batches with variable drug/biomaterial ratio. Prepared batches were subjected for various evaluation studies like particle size, zeta potential, SEM, TEM, surface entrapment, in-vitro diffusion, and stability. Particle size and zeta potential result revealed that all Nano formulation were within range of 133 to 448 with slight negative in charge. SEM and TEM study report indicate that formulations were spherical in shape with less or no aggregation. Less surface entrapment leads to better drug entrapped inside Nano matrix. Bio-Nano formulations were capable of releasing the drug in a slow sustained manner. From the present investigation, it may be concluded that biomaterial isolated from fruits of Ficus carica used in the preparation of bio-nanoparticle act as an efficient carriers for deliver Escitalopram at a controlled rate. It may significantly improve the ability to cross blood-brain barrier and serve as an effective tool to treat Depression disease.

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