Article

Formulation and evaluation of fast dissolving tablets containing a combination of valsartan and amlodipine for the treatment of hypertension

Author : Ujjwal Sidgel, Sheeba FR, Santosh Kuma

The aim of this work was to formulate and evaluate fast dissolving tablets of amlodipine in combination with valsartan for rapid dissolution and absorption of drug to produce rapid onset of action in the management of hypertension. The tablets were prepared using superdisintegrants like crospovidone, croscarmellose, gellan gum, and banana powder. Twelve different groups of formulations (F1F12) were prepared using natural and synthetic superdisintegrants by direct compression method. Tablet weight variation, hardness, friability, drug content, disintegration time and dissolution time were evaluated for each formulation and found satisfactory. From the result, it was concluded that F3 was the best formulation among all other groups.


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