Article

Formulation and evaluation of orodispersible tablet of clinidipine by sublimation method

Author : Gaurav Agarwal, Shilpi Agarwal, Renu Kamboj, P.K. Karar

The aim of the present investigation was to develop oral disintegrating tablets of Cilnidipine. Oral disintegrating tablets (ODTs) by sublimation method. Disintegration time, resistance to crushing of tablets, porosity, friability, disintegration time and dissolution profiles of ODTs were investigated. All tablet formulations disintegrated within one minute and fulfilled the three minute disintegration time required for ODTs as given in European Pharmacopoeia. No interaction or changes were found between active substance and excipients. As a result of the studies, ODT formulations developed in this study can be suggested as promising formulation which assist development and manufacturing of orodispersible tablet of Cilnidipine.


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