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Halophilic Exopolysaccharide Isolated from Swamithope Salt Pans Induce Cell Death through Apoptosis in A549, MCF-7, HT-29 Cancer Cells

Author : S.R. Ramya, and K.R.T Asha

Bacteria that are adapted to live in high salt concentrations were isolated from crystalline salt works of Swamithope, India. Selected strains were observed for the production of extra polymeric substances. 16S rRNA sequence of the selected strain revealed that the isolate belongs to the genus Virgibacillus. After routine analysis of microbial and biochemical methods, the polysaccharide was partially purified and identified as surfactant. The compound showed good emulsifying properties with various oils. GC MS studies revealed the presence of diphenyl-methane, methyl-D-glucose, enolide, cobalt, dicyano-methylene, phenoxaphosphine, benzene and ethanol derivatives in the compound. Pharmacological screening of antibacterial and anticancer assays showed inhibition effect towards various bacterial pathogens and cancer cells. Cell proliferation assay results growth inhibition effect towards A549, MCF-7 & HT-27 cell lines which increases upon sample concentration. As per our findings it is clear that certain exopolysaccharides possess multiple applications which can be useful for industrial applications and to develop new drugs.


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