Modulatory effects of plant extracts on proliferation of T-lymphocytes in vitro stimulated with concanavalin A

Author : Farid Abd-Elrehim Abd-Elaziz Badria, Fatma Mohamed Abdel Rahman Abdel Bar, Diaaeldin Mohamed Abdelkawi Elimam, Mohammad Hosam El-Deen Zaghloul

Herbal drugs are believed to enhance the natural immunity of the human body against viral and microbial infection and improve response; their immunomodulatory activities have been reported in numerous plants. In this study, fifty plant alcoholic extracts were screened for their potential immunomodulatory activity using in-vitro human lymphocyte transformation assay (LTA). Among the screened extracts, Aralia victoria, Boswellia carteri, Cyperus rotundus, Ginkgo biloba, Glycyrrhiza glabra, Olea europaea and Rosmarinus officinalis were capable to induce 96.67%, 32.22%, 11.11%, 5.56%, 25.56%, 13.33% and 2.22% respectively of lymphocyte transformation in comparison to Concanavalin-A (20.5%). Subsequently, each extract was further subjected to bio-guided fractionation using LTA. The bio-guided fractionation revealed that Dichloromethane and Petroleum-ether fractions from Glycyrrhiza glabra and Boswellia carteri stimulate the transformation of human lymphocytes by 86% and 28% respectively. This finding stimulated the interest to pursue a comprehensive study on the possible contribution of the commonly known and structurally related triterpens of Glycyrrhiza glabra and Boswellia carteri and their derivatives as potential immunomodulators and their possible use as immune enhancer in many infectious and cancer diseases.

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