Article

Nano cocoons A novel stimuli-responsive drug delivery system

Author : B. Swathy

A bio-inspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease -degradable DNA nanoclew embedded with acid-responsive DNAse I. Nanocapsule was developed for targeted cancer treatment. The NCl was assembled from a long chain single stranded DNA synthesized by the rolling circle amplification. Multiple GC-pair sequences were integrated in the NCl for enhanced loading capacity of anticancer drug. Meanwhile, negatively charged DNAse I was encapsulated in a positively charged acid-degradable polymeric nanogel to facilitate decoration of DNAse I into NCl by electrostatic interaction. At an acidic environment, the activity of DNAse I was activated due to the acid-triggered shedding of the polymeric shell of NCa, resulting in the cocoon-like self-degradation of NCl and promoting the release of drug for enhanced therapeutic efficacy.


Full Text Attachment

Creative Commons License World Journal of Pharmaceutical Science is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at www.wjpsonline.org. Permissions beyond the scope of this license may be available at www.wjpsonline.org.