Pharmacological Activity of Nigella Sativa: A Review

Author : Zafar K, Noorul H, Nesar A, Vartika S, Khalid M, Prashant S, Zeeshan A, Zohrameena S

Nigella sativa (NS) are dark, thin, and crescent-shaped, seeded shrub belonging to the family Ranunculaceae, commonly growing on Mediterranean coasts in Saudi Arabia, northern Africa and Asia. It is a widely used medicinal plant throughout the world. It contains many active components including nigellicine, nigellimine, nigellidine and alphahederin, thymoquinone, thymohydroquinone, dithymoquinone, thymol, carvacrol. It was reported to possess numerous pharmacological effects related to several organs of the body. It is clear that most of the potent and fruitful activity resides in its volatile oil and a protein component. However, the volatile oil suffers the drawback of the bronhoconstricting effect of thymoquinone. The positive roles of Nigella sativa (NS) has been suggested to have antioxidants on brain development and learning and memory and neuroprotective effects. It has been recommended for using on regular basis in Tibb-e-Nabwi (Prophetic Medicine). It has been widely used as antihypertensive, liver tonics, diuretics, digestive, anti-diarrheal, Extensive studies on N. sativa have been carried out a wide spectrum of its pharmacological actions which may include antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator.

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