Phytochemical analysis, antibacterial property and molecular docking studies of Mammea suriga kosterm

Author : Sudhesh L. Shastri, V. Krishna, Ravi Kumar S, Santosh Kumar S. R, Venkatesh, Pradeepa K

Mammea suriga is an endemic, medicinal and economically important tree belonging to the family Callophyllaceae, distributed along the Western Ghats of India. The present study focuses on phytochemical aspects, antibacterial activity against clinical pathogenic bacterial strains and docking studies of extracts of M. suriga. The GC-MS analysis of flower bud oil showed 69 phytocompounds among them Benzene,1,1'-(1-methylethylidene) bis [4-(2-propenyloxy)- and Cholestan-19-ol,5,6-epoxy-3-fluoro-,(3.beta., .alpha.,6.alpha.) are the major components. Stem bark extract showed 48 phytocompounds among them 17-Oxo-6. alpha. -pentyl-4-nor-3, 5-secoandrostan-3-oic acid methyl ester is the major components. The stem bark and flower bud extract exhibited significant antibacterial activity against S. Typhi (7.000.33) when compared to standard drug (7.000.00). In silico, molecular docking studies revealed that Cholestan-19-ol,5,6-epoxy-3-fluoro-,(3.beta., 5.alpha.,6.alpha.) a second major component of flower bud oil exhibited more efficiency against the key enzyme of bacterial G6PS. This investigation supports the medicinal claim of suragi oil as an effective antibacterial agent.

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