Prevalence of hepatitis-b surface antigen among pregnant women with maternal and perinatal outcome

Author : Brig Vinod Raghav, Col Yoginder Singh, Pratap Shankar, Rakesh Kumar Dixit

Hepatitis B virus infection is still a major public health concern all over the world, and much research must be carried out on the various aspects of this issue. Since infection with hepatitis B virus in pregnant mothers is a threat for both mother and her fetus, this study was performed to determine the relationship between maternal HBsAg carrier status and perinatal outcome. A retrospective case control study was carried out over a 10 year period from April 2005 to March 2015 on HBsAg positive women attending the outdoor and labor ward. The study included 40 HBsAg positive women with singleton pregnancy from April 2005 to March 2015 as case group, and 40 HBsAg negative women with singleton pregnancy, randomly taken as control group. The result of the routine antenatal HBsAg screening was retrieved from patient records. Two groups were matched for parity. Only singleton pregnancies were selected and no patients were diagnosed to have had active hepatitis at any time during their pregnancy. The clinical information of the cases and controls were extracted from medical records. The demographic characteristics including, parity, past medical history, and antenatal complication such as gestational hypertension (PIH), gestational diabetes (GDM), preterm labor (PTL), preterm premature rupture of membrane (PPROM), premature rupture of membrane (PROM), Superimposed PIH, ante partum hemorrhage, post partum hemorrhage and increased hospitalization period after delivery were retrieved from the obstetric records. Perinatal data including neonatal birth weight, intrauterine fetal death (IUFD), still birth, and NICU admission were extracted from the neonatal records. After retrospective study it has been found that HBsAg carriers have increased risk of hospitalization period after delivery, GDM, preterm labor, gestational hypertension, preterm premature rupture of membranes and their infants have increased intrauterine fetal death, and NICU admission.

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