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Protective Effect of Agaricus bisporus (Button mushroom) on Cisplatin Induced Nephrotoxicity in Albino Rats

Author : R. Rajasekar and K. Jeyaprakash

The present study was carried out to investigate the nephroprotective effect of Agaricus bisporus extract on nephrotoxicity induced by cisplatin in male albino rats .Rats were randomly divided in to four groups. Group I was treated as normal control. Group II was treated with single intraperitonial dose of cisplatin (16mg/kg body weight) on 1st day. Group III was treated with single intraperitonial dose of cisplatin on 1st day which is followed by the oral dose of silymarin (50mg/kg body weight/day) from 2nd day to 15thday. Group IV was treated with single intraperitonial dose of cisplatin on 1st day which is followed by the oral dose of Agaricus bisporus (200mg/kg body weight/day) from 2nd day to 15thday. Biochemical results of Agaricus bisporus treated group showed a decreased in levels of blood urea, uric acid, blood urea nitrogen and creatinine and increased in body weight, albumin and total protein when compared to cisplatin treated groups. Hematological results of Agaricus bisporus treated group also showed an increased in levels of Hb, RBC, WBC, PCV, MCV and MCHC when compared to cisplatin treated rats. The results of this study were concluded that Agaricus bisporus protected the rats from the deleterious effect of cisplatin.


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