Article

Screening of in-vitro Thrombolytic and Membrane stabilizing activities of methanolic extract of Launaea sarmentosa

Author : Md. Shalahuddin Millat, Md. Saddam Hussain, Mohammad Tohidul Amin, Md. Mizanur Rahman Moghal, Israt Jahan Ira, S. M. Naim Uddin

The present study was undertaken to analyze in vitro thrombolytic and membrane stabilizing activities of methanolic extract of Launaea sarmentosa. L. sarmentosa is a plant of Asteraceae family. Crude methanolic extracts of L. sarmentosa at numerous conc. were used for in vitro thrombolytic and membrane stabilizing studies. Just in case of thrombolytic study, it absolutely was dose dependently enhanced, where 10 mg/ml concentration most importantly showed 22.57% lysis of clot (p< 0.001) by in vitro clot lysis assay methodology. Streptokinase was used as standard & distilled water was treated as negative management. Crude methanolic extracts of L. sarmentosa dose dependently enhanced in membrane stabilizing activity, whereas 10 mg/ml concentration most significantly showed 12.11% & 20.23% inhibition of haemolysis severally by each hypotonic solution and heat induced haemolysis. Acetyl salicylic acid was used as standard in membrane stabilizing study.


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