Serum Levels of IL-17A in Iraqi Female Patients with Endometriosis

Author : Amina Mohammed Ali; Batool Hassan AL-Ghurabi; Mohammed I Nader

Endometriosis is a common disorder defined as the growth of endometrial tissue outside the uterine cavity. Cytokines have been implicated in the pathogenesis of endometriosis. Aim of the present study is to estimate serum levels of IL-17A, and to investigate whether IL-17A could be used as marker of susceptibility in endometriosis. Fifty female patients with endometriosis their age range (19 – 46) years and 30 apparently healthy females their ages were matched with patients were enrolled in this study. The diagnosis of patients was made by the consultant medical staff, which was based on clinical and ultrasonic laborscopy examinations. Serum level of IL-17A was measured in patients and controls by ELISA. The present findings showed that mean serum level of IL-17A was significantly elevated in females patient as compared with healthy females (P<0.001), On the other hand, there is high significant differences (p<0.001) in serum concentration of IL-17 among stages of disease, and high concentration was found in patients with stage 4 ‘sever endometriosis’. This study demonstrates that serum level of IL-17A could be used as marker of susceptibility in endometriosis, and may play an important role in pathogenesis of this disease.

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