Article

Solid dispersion and air suspension techniques for obtaining controlled drug delivery system containing ketorolac and paracetamol

Author : El-Gizawy S. A, Zein El Din E. E, Sherin Hammad and Yassin H. A

The present study reports on the formulation of ketorolac tromethamine loaded Eudragit RS100, Eudragit RL100 as well as Ethyl cellulose as a controlled release drug delivery system. Solid dispersion and microencapsulation by air suspension method were the techniques for choice. Paracetamol was added to the prepared formulations in the form of physical mixture in order to make use of the synergistic effect of the drug with different non-steroidal anti-inflammatory drugs (NSAIDs).


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