Sublingual drug delivery system: An overview
Drug delivery via oral mucosa is considered to be the most promising route for administration of most of the drugs in pharmacy. Sublingual route is one of the non-invasive and excellent routes for administration of drug candidate. This route is very much familiar in pediatric, geriatric, psychiatric patients who face problem of dysphagia (difficulty in swallowing). Sublingual means ‘beneath the tongue’, i.e incorporating the substance via oral route in such a way that the drug would directly go into the systemic circulation after getting rapidly absorbed in vascular tissues below tongue. In the recent years, sublingual route has put inevitable place lots of advantages like bypassing hepatic first pass metabolism, self-medication, and acceptable bioavailability and improved patient compliance. In terms of permeability, sublingual area of oral cavity is more permeable than buccal area which in turn is more permeable than palatal area. This review emphasizes an updated review on sublingual dosage forms. It includes factors affecting sublingual absorption, merits and demerits, various in-vitro and in-vivo evaluation parameters and commercially available sublingual dosage forms.
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