Article

Synthesis N-(4-methoxybenzoyl)-N’phenylurea and the central nervous system depressant test

Author : Bambang Tri Purwanto

Synthesis the new compound N-(4-methoxybenzoyl)-N’phenylurea has been done. The Schotten Baumann method was used for the reaction between N’phenylurea and 4-methoxybenzoyl chloride. The CNS depressant activity test was done for the N-(4-methoxybenzoyl)-N\'phenylurea compound by Barbituric Sleeping Time (BST) method and compared with bromisoval as the standard compound and also with the parent compound N-benzoyl-N’phenylurea. The compound yield was 73,24% , had a white crystal and gave one spot in Thin Layer Chromatography with two different eluents. The compound melting point was different from the N’phenylurea and showed greater. The structure identification from the new compound was analysed by UV, IR, 1-HNMR and MS, the result showed that the new compound was N-(4-methoxybenzoyl)-N’phenylurea. The CNS depressant activity test from N-(4-methoxybenzoyl)-N’phenylurea had a greater activity if compare with the standard compound bromisoval and also with the parent compound N-benzoyl-N’phenylurea.


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