Synthesis, characterization and evaluation of new benzimidazole derivatives

Author : Saritha Garrepalli, Sandyarani Tatipamula, Anjali Gade, Kavya Yadelli, Rashmi Guggila

A series of new benzimidazole derivatives have been synthesized by simple condensation (Schiff reaction) reaction between benzimidazole derivatives and substituted aromatic aldehydes. All these compounds were characterized by FT-IR, 1HNMR, Mass spectral and TLC analysis thus compounds were screened for antibacterial and antifungal activities respectively. The antibacterial activities were compared with the standard drug such as norfloxacin and antifungal activities were compared with fluconazole. Among synthesized compounds, the compound with 4 chloro IV b on the aromatic ring possessing good antibacterial activity, however lower than standard norfloxacin and the compound with 4 dimethyl amine group IV d showed better antifungal activity; almost similar to that of standard, fluconazole thus they could be promising candidates for novel drugs.

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