Article

Synthesis of Mannich bases of pyrazolines derivatized with 1,3,4-oxadiazoles as antimicrobial agents

Author : Arunkumar Shirahatti, Mahesh Kumar K, Sachin Ambekar, Kotresh O

Mannich bases 3a-h using the morpholine and 5-methyl-4-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-1,3,4-oxadiazol-2(3H)-ones 2a-h were prepared. The structures of the title compounds have been characterized by IR, 1H NMR, MS and elemental analyses. These previously unknown Mannich bases 3a-h were subjected to their antimicrobial activity studies. The compound 3c and 3f showed potent inhibition against treated strains.


Full Text Attachment

Creative Commons License World Journal of Pharmaceutical Science is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at www.wjpsonline.org. Permissions beyond the scope of this license may be available at www.wjpsonline.org.