The Attenuation Effects of Apigenin, Vitexin, Hyperoside and Quercetin on Carrageenan-Induced Mice Tail Thrombosis Model
Flavonoids exert different pharmacological actions, such as analgesic, anti-inflammatory and cardioprotective activities Apigenin, vitexin, quercetin and hyperoside are flavonoids found within medicinal plants. We aimed to study selected flavonoidsí antithrombotic effects using a carrageenan-induced tail thrombosis model in mice. To evaluate the antithrombotic effects of selected flavonoids, a carrageenan-induced tail thrombus mouse model was used. Flavonoids were administered intraperitoneally in doses of 50, 100 and 200 mg/kg. Forty μl (1%) carrageenan (type I) injected in the mouseís hind paw 45 min after drug administration. The wine-colored region at the mouse tail was then measured at 24, 48 and 72 h. The findings showed that all flavonoids tested had antithrombotic effects. A dose of 200 mg/kg of quercetin and hyperoside decreased the length of tail thrombosis significantly (P<0.001) at day three. Apigenin and vitexin were more effective at 50 and 100 mg/kg doses than at the 200 mg/kg dose. The results obtained indicate that selected flavonoids exert preventive anticoagulant effects. Apigenin and vitexin showed antithrombotic effects at all tested doses, while quercetin and hyperoside were effective only at the highest doses. We believe that these flavonoids are promising new antithrombotic agents or could be used as complementary therapy with other anticoagulant drugs.
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